| 河豚毒素对小鼠镇痛作用的实验研究 |
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| 引用本文： | 于丽华,周力,谢克勤.河豚毒素对小鼠镇痛作用的实验研究[J].山东大学学报(医学版),1999(2). |
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| 作者姓名： | 于丽华 周力 谢克勤 |
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| 作者单位： | 山东医科大学毒理学实验室，济南长虹医院 |
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| 摘 要： | 为探讨河豚毒素（ＴＴＸ）镇痛作用与剂量的效应关系，应用化学刺激和热刺激法研究了ＴＴＸ对小鼠的镇痛作用。结果表明，腹腔注射ＴＴＸ０．５、１、２μｇ／ｋｇ，小鼠扭体抑制率分别为２９．５７％、４３．４７％和７６．１２％；在小鼠甩尾试验中，ＴＴＸ１μｇ／ｋｇ腹腔给药后３０～６０ｍｉｎ镇痛作用明显，与对照组比较，Ｐ＜０．０１；２ｇ／ｋｇ剂量组给药后１５ｍｉｎ痛阈达高峰，９０ｍｉｎ内镇痛作用显著（Ｐ＜０．０１），２ｈ内痛阈仍高于对照组；小鼠热板试验也显示随剂量增加镇痛作用加强，但总体敏感性较差，提示ＴＴＸ确有镇痛作用并有剂量－效应关系。
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| 关 键 词： | 河豚毒素 疼痛测定 小鼠 |
THE STUDY ON THE ANALGESIA EFFECT OF TETRODOTOXIN |
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| Yu Lihua,Zhou Li,Xie Keqin.THE STUDY ON THE ANALGESIA EFFECT OF TETRODOTOXIN[J].Journal of Shandong University:Health Sciences,1999(2). |
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| Authors: | Yu Lihua Zhou Li Xie Keqin |
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| Abstract: | The analgesia effect of tetrodotoxin(TTX) in mice treated with chemical and thermal stimuli was studied. The results demonstrated that the rates of spasm in mice injected TTX 0.5g/kg, 1.0g/kg,2.0g/kg abdomenally were 29.57%,43.47% and 76.12%, respectively. Compared with control group, the mice treated with TTX 1g/kg manifested obvious analgesia effect during 3060 minutes(P<0.01); the pain threshold of the mice injected abdomenally TTX 2g/kg reached maximum in 15 min and had analgsia effect in 2 hours (P<0.01). The results indicatecd that TTX had analgesia effect and dose-effect relation. The analgesia effect increased along with the dose in the hot plate experiment, but total sensitivity was not very good. |
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| Keywords: | Tetrodotoxin Pain measurement Mice |
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