The effect of pregnant mare serum gonadotropin on mouse embryos fertilized in vivo or in vitro |
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| Authors: | Fumihiko Sato Richard P. Marrs |
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| Affiliation: | (1) Section of Endocrinology Infertility, Department of Obstetrics and Gynecology, USC School of Medicine, Los Angeles, California;(2) Department of Obstetrics and Gynecology, USC School of Medicine, Women's Hospital, 1240 North Mission Road, 90033 Los Angeles, California |
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| Abstract: | The effect of increasing doses of exogenous gonadotropin stimulation for ovarian hyperstimulation was studied utilizing mouse embryos fertilized in vivo or in vitro. Increased rates of embryo degeneration, fragmentation, and triploidy, increased sister-chomatid exchange, and decreased fertilization rates were observed in high-dose stimulation groups. It appears, therefore, that oocyte and/or embryo quality may be affected by increased amounts of exogeneous gonadotropin stimulation.Presented in part at the American Fertility Society, New Orleans, Louisiana, April 2–7, 1984. |
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| Keywords: | sister-chromatid exchange chromosomal aberration triploidy |
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