酪氨酸肼对着床前大鼠子宫胞浆雌二醇受体含量的影响

子宫内局部给酪氨酰肼１．５ｈ后，子宫胞浆雌二醇受体（ＥｃＲ）量明显下降，３ｈ下降最明显，５ｈ后这种作用基本消失。选择给药３ｈ后为最佳作用时间，观察到酪氨酰肼使子宫ＥｃＲ下降的作用是剂效关系。酪氨酰肼使妊娠ｄ１、ｄ３、ｄ５大鼠子宫ＥｃＲ含量下降。血清雌激素（Ｅ）和孕激素（Ｐ）浓度在给药前和给药３ｈ后无显著性差异。去卵巢１０ｄ大鼠，在给酪氨酰肼３ｈ后，子宫ＥｃＲ也降低。提示酪氨酰肼的这种作用是对子宫的直接作用，而不依赖卵巢内源性雌激素和孕激素。

The Effect of Tyrosine Hydrazide on the Content of the Cytosol Estradiol Receptor of the Uterus in Preimplantation Rat

The effect of tyrosine hydrazide on the uterine cybosol egtradiol receptor(EcR)content in the rat was studied. The EcR content of the uterine horns began to be reduced at 1. 5 h after intrauterine administration of 2mmol/L Tyr hydrazide(0.1ml),with further reduction at 3 h and returned to that of the control horn at 5 h.This effect of Tyr hydrazide occurred in dose-dependent manner.2mmol/L Tyr liydrazide could also decrease the uterine EcR content of preimplantation rats on d1,d3,d5,by 38.42%,32.26%,33.4%.The serum estrogen(E)and progesterone(P)concentrations measured 3 h after giving Tyr hydrazide on d1.d3.d5 showed no significant differences from that of the eontrol group.In ovarietomizied rats the uterine EcR contents were also reduced by 57.7% 3 h after the administration of tyrosine hydrazide.Therefore,it was suggested that the decrease of the EcR contents may be due to a direct effect of Tyr Hydrazide and not be related to the endogenous E and P concentrations.