奥沙利铂联合亚叶酸钙与5-氟脲嘧啶治疗老年晚期结直肠癌的临床研究

目的评价国产奥沙利铂（L-OHP）联合亚叶酸钙（CF）、5-氟脲嘧啶（5-Fu）治疗局部晚期或转移性老年结直肠癌患者（≥70岁）的临床疗效及毒副反应。方法入组30例患者，方案L-OHP130mg／m^2静脉滴注2h，第1天；CF200mg／m^2静脉滴注2h，第1～5天；5一Fu425mg／m^2静脉滴注6h，第1-5天。每3周重复，两周期后评价疗效。结果30例患者均可评价疗效，无CR病例，PR15例，SD8例，PD7例，有效率为50％，中位生存期18个月，中位无进展生存9．5个月，1年生存率为66.7％。主要毒副反应为神经毒性，中性粒细胞减少，消化道反应及腹泻。结论L-OHP联合5-Fu／FA方案治疗局部晚期或转移性老年结直肠癌患者疗效较高，耐受性较好，值得进一步研究。

The Clinical Study of 5-Fluorouracil, Calcium Folinate and Oxaliplatin in Old Patients with Advanced Colorectal Cancer

Objective To evaluate the efficacy and toxicity reaction of 5-Fluorouracil Calcium folinate and Oxaliplatin in old patients with advanced colorectal cancer. Methods Thirty patients over 70 years old with advanced colorectal cancer were enrolled. The chemotherapy regimen consisted of Oxaliplatin 130mg/m^2 iv.gtt. 2 hours dl, CF 200mg/m2 iv.gtt. 2 hours dl-5, 5-Fu 425mg/m2 iv.gtt. 6 hours dl-5. The patients were repeatedly treated every 3 weeks and evaluated the efficacy after 2 cycles. Results All eligible patients were assessed for response, none achieved a complete re- sponse, 15 patients achieved a confirmed partial response. The overall response rate was 50%, the median PFS was 9.5 month, the median OS was 18 month and the 1 year survival rate was 66.7%. Conclusion 5-Fluorouracil, Calcium folinate and Oxaliplatine represents a well-tolerated active pal- liative regimen for patients with colorectal cancer over 70 years old.