慢性化脓性中耳炎分泌物的病原学研究

目的研究慢性化脓性中耳炎(CSOM)主要病原菌的种类及对抗生素的耐药情况.方法对135例CSOM患者的中耳脓性分泌物进行细菌培养,对分离的病原菌进行药物敏感试验.结果分离出病原菌119株,以金黄色葡萄球菌(45株)为主,其次是棒状杆菌(17株)和真菌(13株).金黄色葡萄球菌对青霉素、庆大霉素、奈替米星耐药率高,分别为94%、64%、61%,对喹诺酮类、利福平、万古霉素、磺胺类敏感性高.棒状杆菌对青霉素、氯洁霉素、磺胺类、苯唑西林耐药性高,分别为54%、60%、60%、40%,对庆大霉素、环丙沙星、利福平、万古霉素、复方氨苄西林敏感性高.结论金黄色葡萄球菌、棒状杆菌、真菌是CSOM的主要病原菌.以上细菌对青霉素类抗生素耐药性均高,对喹诺酮类、利福平、万古霉素均敏感.近年真菌感染率有增高趋势应引起临床医生足够重视.

The secretion pathogenic study of chronic suppurative otitis media

Objective To investigate the main secretion pathogens of ch ronic suppurative otitis media(CSOM)and their antibiotics resistance conditions. Methods The secretion of135cases CSOMwere bacteria cultivated and the separated pathogens were performed drug sensitive test. Results The separated pathogens had119strains,the most was staphylococcus aureus(45strains)and the secondary was corynebacterium(17strains)and fungus(13strains).The drug resistance incidences of staphylococcus aureus to penicillin,gentalline and netilmicin were94%,64%and61%respectively.The sensitive drug of staphylococcus aureus were quinolone,ripampicin,vancomycin and sulfanilamide.The drug resistance incidences of corynebacterium to penicillin,clindamicin,sulfanilamide and oxacillin were54%,60%,40%and40%respectively.The sensitive drug of corynebacterium were gentalline,cinrofloxacin,ripampicin,vancomycin and co-ampicillin. Conclusion The main pathogens of CSOMwere staphylococcus aureus,corynebacterium and fungus,all of which were drug-resistant to penicillin and sensitive to ripampicin and vancomycin.Recently,fungus infection incidence had increasing trendency in CSOM,which should be paid enough attention to in all clinic doctors.