层次分析法区分同品种药物质量差异研究

目的:区分不同厂家生产的注射用头孢哌酮舒巴坦钠的质量差异,进行质量优劣排序。方法:根据层次分析法的原理和步骤,利用影响头孢哌酮舒巴坦钠的质量的3个指标,建立了3个判断矩阵,计算了判断矩阵的权重,分别在等权和不等权情况下,得到了层次总排序向量。结果:等全处理时,11个厂家生产的CPZ/SBT质量顺序从优到差依次为:D>C>F>G>A>J>I>B>E>H>K;不等全处理时,CPZ/SBT质量顺序从优到差依次为:D>C>F>G>A>I>J>B>E>H>K。结论:用层次分析法区分同品种药物质量差异具有一定可行性。

Study on Distinguish the Quality Difference of the Same Sort of Drug based on Analytic Hierarchy Process

Objective: To distinguish the quality of Cefoperazone Sodium and Sulbactam Sodium(CPZ /SBT) for Injection manufactured by different plants and to make quality comparison between them.Methods: Based on the theory and step of analytic hierarchy process,and according to three index affecting the quality of CPZ/SBT,and set up three judgement matrix,and calculate the index weight,and get priority vector of hierarchy at the condition of equal and unequal index weights,respectively.Results: The order of CPZ/SBT quality of 11 plants is D>C>F>G>A>J>I>B>E>H>K at the condition of equal index weights;while the order of CPZ/SBT quality of 11 plants is D>C>F>G>A>I>J>B>E>H>K at the condition of unequal index weights.Conclusion: It is feasible to distinguish the quality difference of the same sort of drug by using Analytic Hierarchy Process.