| 弱精子症所致男性不育患者精浆中NO含量测定意义 |
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| 引用本文： | 王志峰,徐乐,蒋杰宏,邱敏捷,姚聪,黎灿强,杨毅. 弱精子症所致男性不育患者精浆中NO含量测定意义[J]. 数理医药学杂志, 2013, 26(2): 181-183 |
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| 作者姓名： | 王志峰 徐乐 蒋杰宏 邱敏捷 姚聪 黎灿强 杨毅 |
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| 作者单位： | 王志峰 (南方医科大学附属何贤纪念医院,广州,511400)；徐乐 (南方医科大学附属何贤纪念医院,广州,511400)；蒋杰宏 (南方医科大学附属何贤纪念医院,广州,511400)；邱敏捷 (南方医科大学附属何贤纪念医院,广州,511400)；姚聪 (南方医科大学附属何贤纪念医院,广州,511400)；黎灿强 (南方医科大学附属何贤纪念医院,广州,511400)；杨毅 (南方医科大学附属何贤纪念医院,广州,511400)； |
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| 摘 要： | 目的:探讨弱精子症患者精浆中一氧化氮(NO)含量变化及对精子活力的影响。方法:选择弱精子症患者50例为实验组,同时选择正常健康男性30例作对照组。采用计算机辅助精液分析技术测定各组精子活力,采用硝酸还原酶法测定精浆中NO含量。结果:实验组精浆中NO含量为58.16±12.17μmol.L-1,对照组精浆中NO含量为34.07±3.23μmol.L-1,实验组明显高于对照组,两者比较差异具有统计学意义(P<0.05)。实验组精浆中NO水平与精子活动率水平呈负相关性,具有统计学意义(P<0.05)。结论:弱精子症患者精浆中NO含量增高,并与精子活力呈负相关。
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| 关 键 词： | 弱精子症 精浆 精子活力 一氧化氮 |
Relationship between Nitrion Oxide in Seminal Plasma and Sperm Viability of Asthenospermia Patients |
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| Abstract: | Objective: To investigate the effect of nitric oxide content in serum on motility of asthenospermia patients.Methods: Fifty young men with asthenospermia were enrolled as study group(n=50) and thirty normal men were enrolled as control group(n=30).The content of NO in sperm plasma were measured by nitricacid reductase method,and the semen viability were determined by computer assisted semen analysis(CASA).Results: The mean NO content of study group's seminal plasma is 58.16±12.17μmol·L-1.In control group,the mean NO content is 34.07±3.23μmol·L-1.The difference was significant.(P<0.05).Linear correlation analysis indicated that the NO content in the seminal plasma of study group were significantly negatively associated with the sperm motility rate(P<0.05).Conclusion: The NO content in seminal plasma of asthenospermia patients has increased and it is negatively correlated with the sperm viability. |
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| Keywords: | asthenospermia seminal plasma sperm viability nitric oxide |
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