CD30-positive lymphoma in human T-cell leukaemia virus type 1 carrier without monoclonal integration of HTLV-1 |
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| Authors: | Mitsuo,Hori ,Shouichi,Mitsuhashi ,Toshitaka,Kobayashi ,Toshiro,Nagasawa ,Naoyoshi,Mori,Masanao,Miwa&dagger ,Tsukasa,Abe |
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| Affiliation: | Divison of Haematology, Institute of Clinical Medicine, University of Tsukuba;Department of Pathology, School of Medicine, Nagoya University;Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Japan |
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| Abstract: | Summary. CD30, Ki-1 antigen, an activated T-cell antigen, is a member of the nerve growth factor receptor family. This antigen is expressed on the lymphoma cells of some adult T-cell leukaemia/lymphoma (ATL/L) patients and some patients with Epstein-Barr virus infection. CD30-positive large cell cutaneous T-cell lymphomas occasionally integrate a defective HTLV-1 provirus. We describe here an HTLV-1 carrier who developed Ki-1 lymphoma with no evidence of monoclonal integration of the HTLV-1 proviral sequence. |
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| Keywords: | HTLV-1 ATL/L CD30 (Ki-1) monoclonal integration carrier |
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