Anti-BiP antibody levels in juvenile idiopathic arthritis (JIA) |
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| Authors: | Bodman-Smith M D Fife M F Wythe H Corrigal V M Panayi G S Wedderburn L R Woo P |
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| Affiliation: | Oncology, St George's Hospital Medical School, 1 Centre for Paediatric Rheumatology, University College London,2 Rheumatology, GKT School of Medicine and3 Rheumatology Unit, Institute of Child Health, University College London, London, UK |
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| Abstract: | SIR, We have previously described the human heat shock proteinBiP (immunoglobulin binding protein; glucose regulated protein78) as an autoantigen in rheumatoid arthritis [1]. Antibodiesto BiP have been described in the serum of RA patients by ourselvesand other groups [2, 3] and we have recently described anti-BiPantibodies in the synovial fluid of RA patients and the serumof patients with primary Sjögren's syndrome [3]. Moreoveranti-BiP antibodies have been shown to be elevated in animalmodels of arthritis [1]. The functions |
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