Evaluation of the nephrotoxicity of iproplatin (CHIP) in comparison to cisplatin by the measurement of urinary enzymes |
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Authors: | Lakshmi Pendyala Stefan Madajewicz Shashikant B Lele Susan G. Arbuck Patrick J. Creaven |
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Affiliation: | (1) Department of Clinical Pharmacology and Therapeutics, Roswell Park Memorial Institute, New York State Department of Health, 14263 Buffalo, NY, USA;(2) Department of Gyrecologic Oncology, Roswell Park Memorial Institute, New York State Department of Health, 14263 Buffalo, NY, USA;(3) Department of Surgical Oncology, Roswell Park Memorial Institute, New York State Department of Health, 14263 Buffalo, NY, USA |
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Abstract: | Summary Levels of three enzymes, leucine aminopeptidase (LAP), N-acetyl- -D-glucosaminidase (NAG), and -glucuronidase (BGA) were measured in the urine of patients receiving hematologically toxic doses of iproplatin (a) with or (b) without pretreatment hydration. The maximum post-treatment increases in the levels of each of the enzymes were compared between these two groups of patients. In addition, the maximum increases in urinary enzyme levels in iproplatin-treated patients were compared with those in patients treated with 40 mg/m2 cisplatin, a known nephrotoxic agent.Increases in LAP levels after cisplatin treatment in the periods studied are significantly higher than those after iproplatin treatment (P0.05). No differences were found in the increases in BGA and NAG levels between iproplatin treatment and cisplatin treatment. No differences were found in the increases in levels of any of the enzymes between patients receiving iproplatin with pretreatment hydration and no prior hydration.The work reported in this paper was supported in part by grant CA-21071 from USPHS NCI and by Bristol Myers Co. |
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