Health-Related Quality of Life and Treatment Satisfaction in North American Patients with Primary Immunedeficiency Diseases Receiving Subcutaneous IgG Self-Infusions at Home |
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| Authors: | Uwe Nicolay Peter Kiessling Melvin Berger Sudhir Gupta Leman Yel Chaim M. Roifman Ann Gardulf Florian Eichmann Stefan Haag Cordula Massion Hans D. Ochs |
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| Affiliation: | (1) Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden;(2) Clinical Research, ZLB Behring GmbH, Marburg, Germany;(3) Division of Allergy, Immunology and Rheumatology, Rainbow Babies and Children's Hospital, Cleveland, Ohio;(4) Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California;(5) The Hospital for Sick Children, Toronto, Ontario, Canada;(6) Kendle International Inc., Munich, Germany;(7) Department of Biostatistics, Accovion GmbH, Marburg, Germany;(8) Department of Pediatrics, University of Washington, Seattle, Washington;(9) M96, Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, SE-14186, Sweden |
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| Abstract: | The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patients treated with IVIG at the hospital/doctor's office (Group A) or at home (Group B) before the study started. Forty-four adult North American PIDD patients were included in the study, 28 patients in Group A and 16 in Group B. Patients in Group A reported significantly less limitations with their work/daily activities, a significantly improved vitality, and better general health. Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy. |
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| Keywords: | Primary immunedeficiency disease subcutaneous IgG therapy intravenous IgG therapy home-therapy quality of life treatment satisfaction |
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