| 平喘合剂对哮喘模型大鼠血浆及肺泡灌洗液中内皮素-1含量的影响 |
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| 引用本文： | 邢向晖. 平喘合剂对哮喘模型大鼠血浆及肺泡灌洗液中内皮素-1含量的影响[J]. 中国中西医结合杂志, 2004, 0(Z1) |
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| 作者姓名： | 邢向晖 |
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| 作者单位： | 山东中医药大学 济南250011） |
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| 摘 要： | 目的观察平喘合剂对哮喘模型大鼠血浆及肺泡灌洗液(BALF)中内皮素-1(ET-1)含量的影响,探讨平喘合剂抑制哮喘大鼠气道炎症的作用机理。方法选择雄性大鼠随机分组,制作动物模型,用放射免疫方法监测平喘合剂治疗前后血浆及 BALF 中 ET-1的含量变化。结果平喘合剂可明显降低哮喘模型大鼠血浆及 BALF 中 ET-1的含量,效果明显优于博利康尼组和痰喘丸组。结论平喘合剂可明显抑制 ET-1的分泌,降低血浆及 BALF 中 ET-1的含量,提示本方可能通过抑制炎症介质,抑制气道炎症而发挥治疗哮喘的作用。
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| 关 键 词： | 平喘合剂 哮喘 动物模型 内皮素-1 |
Effect of Pingchuan Mixture on Endothelin-1 Content in Blood Plasma and Bronchoalveolar Lavage Fluid in Rat Model of Asthma |
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| XING Xiang-hui Shangdong TCM University,Jinan. Effect of Pingchuan Mixture on Endothelin-1 Content in Blood Plasma and Bronchoalveolar Lavage Fluid in Rat Model of Asthma[J]. Chinese journal of integrated traditional and Western medicine, 2004, 0(Z1) |
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| Authors: | XING Xiang-hui Shangdong TCM University Jinan |
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| Abstract: | Objective To explore the mechanism of Pingchuan Mixture (PCM) in inhibiting airway inflammation,by way of observing its effect on endothelin-1 (ET-1 ) content in blood plasma and bronchoalveolar lavage fluid (BALF) in rats with asthma.Methods Male rats were randomly divided into groups,the animal model was established and changes of ET-1 content in blood plasma and BALF before and after PCM treatment were examined using RIA.Results PCM could sig- nificantly lower ET-1 content in blood plasma and BALF in model rats,with the effect significantly better than that of Bricanyl and Tanchuan pill.Conclusion PCM could significantly inhibit the secretion of ET-1,lower the content of ET- 1 in blood plasma and BALF,suggesting that it might play the effect in treating asthma through inhibiting inflammatory medium to prevent airway inflammation. |
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| Keywords: | Pingchuan Mixture asthma animal model endothelin-1 |
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