| 胰腺癌基因治疗的研究现况 |
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| 作者姓名： | Wang M Wang YL Lei RQ Feng DX |
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| 作者单位： | 1. 上海第二医科大学,附属瑞金医院胆胰外科,上海,200025
2. Department of Surgery, the Affiliated Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai |
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| 摘 要： | 随着分子生物学和免疫学的发展,肿瘤的发生、发展及转移机制的认识日益加深.胰腺癌基因治疗的探索已经在多方面展开,如抑制癌基因,激活抑癌基因,诱导凋亡和采用基因导向的酶解药物前体治疗及免疫激活等,期待新的靶基因发现及基因技术的新进展,带来该领域的突破性进展.
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| 关 键 词： | 胰腺癌 基因治疗 靶基因 |
| 文章编号： | 1000-503X（2005）05-0648-06 |
| 收稿时间： | 2005-05-28 |
| 修稿时间： | 2005年5月28日 |
Update in the research of gene therapy for pancreatic carcinoma |
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| Wang M,Wang YL,Lei RQ,Feng DX.Update in the research of gene therapy for pancreatic carcinoma[J].Acta Academiae Medicinae Sinicae,2005,27(5):648-653. |
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| Authors: | Wang Min Wang Yi-lin Lei Ruo-qing Feng Dian-xu |
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| Institution: | Department of Biliary and Pancreatic Surgery, the Affiliated Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China |
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| Abstract: | With the advances in immunology and molecular biology, new recognition in the pathogenesis, progression, and metastasis of carcinoma have been achieved. Studies on gene therapy for pancreatic carcinoma have been attempted in different ways, such as inhibiting oncogene, activating tumor suppressor gene, inducing apoptosis, applying gene directed enzyme prodrug therapy, and immune activation. New specific target genes and further development of gene technology may bring the breakthrough in this field. |
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| Keywords: | pancreatic carcinoma gene therapy gene targets |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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