VEGF-C、VEGFR-3和MMP-2在宫颈癌组织中的表达及其与侵袭、转移的关系 |
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引用本文: | 罗晓华,庞霞,张占薪,李宏英,李之昆.VEGF-C、VEGFR-3和MMP-2在宫颈癌组织中的表达及其与侵袭、转移的关系[J].中国妇幼保健,2010,25(36). |
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作者姓名: | 罗晓华 庞霞 张占薪 李宏英 李之昆 |
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作者单位: | 1. 郑州大学第三附属医院妇产科,河南,郑州,450000 2. 郑州大学第一附属医院病理科 3. 郑州大学第二附属医院妇产科 |
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摘 要: | 目的:探讨血管内皮生长因子C(VEGF-C)及其受体VEGFR-3和基质金属蛋白酶-2(MMP-2)在人宫颈癌组织中的表达及其与宫颈癌侵袭、转移的关系。方法:采用免疫组化SP法检测11例正常宫颈组织、19例CIN组织、47例宫颈癌组织中的VEGF-C、VEGFR-3和MMP-2的表达,分析表达结果与病理特征的关系。结果:VEGF-C、VEGFR-3和MMP-2在正常宫颈组织、CIN组织及宫颈癌组织中的表达依次增高(P<0.05);伴盆腔淋巴结转移组VEGF-C、VEGFR-3和MMP-2的表达较无淋巴结转移组明显升高(P<0.05);浸润宫颈深度≥1/2组VEGF-C、VEGFR-3和MMP-2的表达明显高于浸润宫颈深度<1/2组(P<0.05)。结论:VEGF-C、VEGFR-3和MMP-2蛋白的异常表达在宫颈癌发生发展及侵袭、转移过程中起重要作用,联合检测这些指标有助于预测宫颈癌组织的侵袭和转移。
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关 键 词: | 宫颈癌 VEGF-C VEGFR-3 MMP-2 免疫组织化学 |
Expressions of VEGF-C, VEGFR-3 and MMP-2 in cervical carcinoma and their relationship with invasion and metastasis of cervical carcinoma tissues |
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Abstract: | Objective:To explore the expressions of vascular endothelial growth factor C(VEGF-C),VEGF receptor-3(VEGFR-3)and matrix metalloproteinase-2(MMP-2)in human cervical carcinoma and their relationship with invasion and metastasis of cervical carcinoma tissues.Methods:Immunohistochemical S-P method was used to detect the expressions of VEGF-C,VEGFR-3 and MMP-2 in 11 cases of normal cervical tissues,19 cases of CIN tissues and 47 cases of cervical carcinoma tissues,the relationship between expressions of VEGF-C,VEGFR-3 and MMP-2 and pathological characteristics was analyzed.Results:The expression levels of VEGF-C,VEGFR-3 and MMP-2 increased gradually from normal cervical tissues,CIN tissues to cervical carcinoma tissues(P<0.05);the expression levels of VEGF-C,VEGFR-3 and MMP-2 in pelvic lymph node metastasis group were significantly higher than those in non-pelvic lymph node metastasis group(P<0.05);the expression levels of VEGF-C,VEGFR-3 and MMP-2 in cervical invasive depth≥1/2 group were significantly higher than those in cervical invasive depth<1/2 group(P<0.05).Conclusion:The abnormal expressions of VEGF-C,VEGFR-3 and MMP-2 may play an important role in the occurrence,development,invasion and metastasis of cervical carcinoma,joint detection of the indexes may help to predict invasion and metastasis of cervical carcinoma tissues. |
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Keywords: | Cervical carcinoma Vascular endothelial growth factor-C Vascular endothelial growth factor receptor-3 Matrix metalloproteinase-2 Immunohistochemistry |
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