重度子痫前期患者肝肾功能损害研究

目的:探讨重度子痫前期患者肝肾功能损害情况。方法:以2008年1~12月住院的119例重度子痫前期患者为重度子痫前期(S-PE)组,以同期正常单胎晚期妊娠孕妇116例为对照组,采集孕妇清晨空腹静脉血,测定血浆ALT、AST、TP、ALB、Cre及Bun。结果:S-PE组孕妇的ALT值(33.97±10.53)U/L高于对照组的(14.06±13.89)U/L,差异有统计学意义(P0.05);S-PE组孕妇的AST值(44.97±87.38)U/L高于对照组的(20.92±10.18)U/L,差异有统计学意义(P0.01);S-PE组孕妇的TP(57.55±6.37)g/L明显低于对照组的(66.24±5.05)g/L,差异有统计学意义(P0.01);S-PE组孕妇的ABL值(31.59±4.27)g/L低于对照组的(38.56±2.89)g/L,差异有统计学意义(P0.01);S-PE组Cre值(79.72±24.01)μmol/L高于对照组(58.38±6.58)μmol/L,差异有统计学意义(P0.01);S-PE组Bun值为(6.22±3.20)μmol/L,高于对照组的(3.53±0.90)μmol/L,差异有统计学意义(P0.01);S-PE组孕妇24 h尿蛋白定量为(5.69±3.26)g。结论:重度子痫前期患者由于全身小血管痉挛,导致肝肾等重要脏器功能损害,甚至产生多脏器功能衰竭,故应早诊断早治疗。

Study of change of liver and renal function in severe preeclampsia

Objective:To investigate the change of liver and renal function in severe preeclampsia(S-PE).Methods:ALT,AST,TP,ALB,Cre and Bun in blood plasma were measured in 119 cases with severe preeclampsia(S-PE group) and in 116 cases of normogravidas in third trimester(control group) on the empty stomach in morning during the same period in our hospital from January 2008 to December 2008.Results:The value of ALT((33.9±10.53) U/L) in S-PE group was higher than that of in control group((14.06±13.89) U/L)(P<0.05);The value of AST((44.97±87.38)U/L) in S-PE group was significantly higher than that in control group((20.92±10.18)U/L)(P<0.01);The value of TP((57.55±6.37)g/L) in S-PE group was obviously lower than that in control group((66.24±5.05)g/L)(P<0.01);The value of ABL((31.59±4.27)g/L) in S-PE group was significantly lower than that in control group((38.56±2.89)g/L)(P<0.01);The value of Cre((79.72±24.01)μmol/L) in S-PE group was obviously higher than that in control group((58.38±6.58) μmol/L)(P<0.01);The value of Bun((6.22±3.20) mol/L) in S-PE group was significantly higher than that in control group((3.53±0.90) mol/L)(P<0.01).Quantity of urine protein in 24 hours was(5.69±3.26)g in S-PE group.Conclusion:Severe preeclampsia can obviously affected liver and renal function even many organs failure,because of blood vessel convulsion.Earlier diagnosis and treatment should be taken to prevent the failure of more important organs.