获卵数对长方案IVF-ET妊娠结局的影响

目的:探讨获卵数对长方案体外受精-胚胎移植(IVF-ET)妊娠结局的影响。方法:回顾性分析2001年7月~2007年12月于中山大学附属第二医院生殖中心行长方案IVF-ET治疗的1 161对不孕夫妇的1 389个获卵周期。按获卵数分为5组:A组(≤5个),B组(6~10个),C组(11~15个),D组(16~20个),E组(≥21个)。Logistic回归分析获卵数对临床妊娠及累积临床妊娠结局的影响。结果:获卵数与年龄成负相关(r=-0.267,P<0.001);Logistic回归排除年龄因素的影响后,A、E组的临床妊娠率较C组明显下降,OR=0.33,0.51,P<0.05;累积临床妊娠率由A组至D组逐渐升高,D组最高为46.3%,E组略有下降,A、B组相对于C组的OR值分别为0.25和0.70,P<0.05。D、E组与C组相比差异无显著性。结论:长方案IVF中获取中等数量的卵子能获得最佳的临床妊娠率和累积临床妊娠率。

Effect of number of retrieved oocytes on pregnancy outcomes of cases receiving long protocol IVF-ET

Objective:To explore the effect of number of retrieved oocytes on pregnancy outcomes of cases receiving long protocol in vitro fertilization and embryo transfer(IVF-ET).Methods:1 389 retrieval cycles of 1 161 couples with infertility who received long protocol IVF-ET in the hospital from July 2001 to December 2007 were analyzed retrospectively,then the cases were divided into 5 groups according to number of retrieved oocytes: A group(≤5),B group(6～10),C group(11～15),D group(16～20) and E group(≥21);the effects of number of retrieved oocytes on outcomes of clinic pregnancy and accumulated clinic pregnancy were analyzed by logistic regression analysis.Results:There was a negative correlation between number of retrieved oocytes and age(γ=-0.267,P<0.001);multivariable logistic regression analysis showed that the clinic pregnancy rates of A group and E group were significantly lower than that in C group(OR=0.33,0.51,P<0.05) after excluding age factor;the accumulated clinic pregnancy rate increased gradually from A group to D group,the accumulated clinic pregnancy rate of D group was the highest(46.3%),then decreased slightly in E group,the OR values of A group,B group to C group were 0.25 and 0.70,respectively(P<0.05);there was no significant difference between D group,E group and C group.Conclusion:Moderate number of retrieved oocytes may get optimal clinic pregnancy rate and accumulated clinic pregnancy rate in long protocol IVF-ET.