血清TSGF、CA15-3、CEA在乳腺癌中的表达及临床意义

目的:探讨联合检测乳腺癌患者血清中恶性肿瘤特异性生长因子(TSGF)、糖类抗原CA15-3及癌胚抗原CEA在乳腺癌诊断中的价值。方法:采集128例乳腺癌患者、64例乳腺良性疾病患者及30例健康人血液,利用生化比色法测定TSGF含量,利用化学发光免疫法检测CA15-3及CEA含量。结果:乳腺癌组TSGF、CA15-3、CEA含量明显高于乳腺良性疾病组和健康组(P0.05)。乳腺癌组TSGF、CA15-3、CEA阳性率分别为48.4%、36.7%、17.9%。联合检测乳腺癌阳性率为67.9%。结论:单独检测TSGF、CA15-3、CEA对乳腺癌有意义,联合检测提高乳腺癌的诊断率,提高诊断的敏感性和准确性。

Expression levels and clinical significance of serum TSGF, CA15 -3 and CEA in breast cancer

Objective:To explore the value of joint detection of serum tumor specific growth factor(TSGF),carbohydrate antigen15-3(CA15-3) and carcinoembryonic antigen(CEA) in diagnosis of breast cancer.Methods:Serum samples of 128 patients with breast cancer,64 patients with benign breast diseases and 30 healthy women were collected,then the level of TSGF was determined with biochemical colorimetry,and the levels of CA15-3 and CEA were determined with chemiluminescence immunoassay.Results:The serum levels of TSGF,CA15-3 and CEA in breast cancer group were significantly higher than those in benign breast diseases group and health group(P<0.05).The positive rates of TSGF,CA15-3 and CEA were 48.4%,36.7% and 17.9%,respectively.The positive rate of joint detection was 67.9%.Conclusion:Individual detection of TSGF,CA15-3 and CEA is significant in diagnosis of breast cancer,joint detection can increase diagnostic rate of breast cancer and sensitivity and accuracy of diagnosis.