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| 高效液相色谱法测定六味清咽滴丸中苦参碱含量 | |
| 引用本文： | 李伟,杨玉果,管庆海. 高效液相色谱法测定六味清咽滴丸中苦参碱含量[J]. 中国药业, 2007, 16(16): 29-30 |
| 作者姓名： | 李伟 杨玉果 管庆海 |
| 作者单位： | 1. 长春中医药大学,吉林,长春,130021 2. 亚泰万联药业有限公司,吉林,长春,130011 3. 亚泰集团,吉林,长春,130011 |
| 摘 要： | 目的探讨用高效液相色谱（HPLC）法测定六味清咽滴丸中苦参碱含量，建立六味清咽滴丸的质量标准。方法采用YWG-NH2柱，流动相为用磷酸调节pH值为2的乙腈-无水乙醇-水（80：10：10），流速为1．0mL／min，检测波长为220nm，柱温为室温。结果制剂中苦参碱质量浓度在0．2～2．6μg／mL范围内与峰面积线性关系良好。平均加样回收率为97．1％，RSD为1．91％。结论HPLC法灵敏、简便、准确，重现性好，可作为该制剂的质量控制标准。 |
| 关 键 词： | 苦参碱 六味清咽滴丸 高效液相色谱法 |
| 文章编号： | 1006-4931（2007）16-0029-02 |
| 修稿时间： | 2006-11-20 |
Determination of Matrine in Liuweiqingyan Drop Pills by HPLC |
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| Li Wei,Yang Yuguo,Guan Qinghai. Determination of Matrine in Liuweiqingyan Drop Pills by HPLC[J]. China Pharmaceuticals, 2007, 16(16): 29-30 | |
| Authors: | Li Wei Yang Yuguo Guan Qinghai |
| Affiliation: | 1. Changchun University of TCM, Changchun, Jilin, China 130021; 2. Wanlian Pharmaceutical Co., Ltd. Yatai Group, Changchun, Jilin, China 130011; 3. Yatai Group, Changchun, Jilin, China 130011 |
| Abstract: | Objective To establish a HPLC method for the determination of matrine in Liuweiqingyan Drop Pills. Methods The analysis was carried out on YWG- NH2 column by HPLC. The mobile phase was acetonotrile -anhydrous ethanol- water（80 ： 10 ： 10）with pH = 2 adjusted by phosphoric acid. The flow rate was 1.0 mL/min, and the detecting wavelength was at 220 nm. Results Matrine was separated good and had a good liner relationship within the concentration range of 0. 2- 2. 6 μg/mL. The average recovery rate was 97. 1%, RSD = 1.91%. Conclusion This method is accurate, simple and rapid. The result is more satisfactory for the quality control. |
| Keywords: | martine Liuweiqingyan drop pills HPLC |
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