In Vivo Accumulation of nitric oxide in blood vessels |
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| Authors: | B. V. Smirin A. F. Vanin I. Yu. Malyshev D. A. Pokidyshev E. B. Manukhina |
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| Affiliation: | (1) Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow;(2) Institute of Chemical Physics, Russian Academy of Sciences, Moscow |
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| Abstract: | Against the background of NO-synthase blockade, diethyldithiocarbamate had no effect on the tone of isolated rat aorta, but induced relaxation of aorta preparations isolated afterin vivo NO accumulation and isolated aorta incubated with dinitrosyl iron complex. Guanylate cyclase inhibitor methylene blue prevented the relaxation induced by diethyldithiocarbamate. These data suggest that accumulation of NO in the organism can result in its accumulation in the vessel wall. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 6, pp. 629–632, June, 1999 |
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| Keywords: | nitric oxide nitric oxide stores dinitrosyl iron complex adaptation to stress |
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