茶多酚对急性百草枯中毒大鼠治疗作用的实验研究

目的 探讨茶多酚（ｔｅａ ｐｏｌｙｐｈｅｎｏｌｓ，ＴＰ）对急性百草枯中毒的治疗作用方法 大鼠用百草枯（ｐａｒａｑｕａｔ，ＰＱ）灌胃（２５０ｍｇ／ｋｇ）染毒后３ｈ再经口灌注ＴＰ，分别测定染毒后８、２４、４８、７２ｈ大鼠血浆和支气管肺泡灌洗液（ＢＡＬＦ）中丙二醛（ＭＤＡ）含量及超氧化物歧化酶（ＳＯＤ）、谷胶基肽过氧化物酶（ＧＳＨ－Ｐｘ）的活力，并观察肺组织结构改变。结果 ＰＱ染毒后血浆及ＢＡＬＦ中ＭＤ

Experimental study on the therapeutic effect of tea polyphenols against acute paraquat poisoning in rats

Objective To study the therapeutic effect of tea polyphenols(TP) against acute poisoning by paraquat(PQ). Methods SD rats were given(p.o.) TP at 3 h after oral administration of PQ(250 mg/kg).The level of MDA,superoxide dismutase(SOD) and glutathione peroxidase(GSH Px) both in plasma and bronchoalveolar lavage fluid(BALF) were detected at 8,24,48,72 h respectively after TP treatment. Results Compared with control group, the level of MDA in PQ poisoning group increased significantly both in plasma and BALF( P <0.01);SOD in plasma was decreased( P <0.01),GSH Px showed some increase 48 h after poisoning.The activities of SOD and GSH Px in BALF were all decreased,but SOD showed some increase 48 h later.Compare TP treated group with PQ poisoning group,the MDA level decreased both in plasma and BALF( P <0.05),the SOD and GSH Px activities were increased as well( P < 0.05). The pathological changes in lungs caused by PQ were mainly shown as congestion,leukocyte infiltration,thickness and local hemorrhage in alveolar wall.After TP treatment,congestion and hemorrhage of alveoli got some improvement. Conclusion Administration of TP could improve the lipid peroxidation damage caused by acute poisoning of PQ.