鼻息肉组织中白细胞介素-5和粒细胞巨噬细胞集落刺激因子水平测定及其意义

目的探讨鼻息肉组织中嗜酸粒细胞浸润与白细胞介素-5(interleukin-5,IL-5),粒细胞巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulation factor,GM-CSF)水平关系及其意义.方法应用酶联免疫吸附测定(enzyme linked immunosorbent assay,ELISA)法检测38例鼻息肉组织匀浆中IL-5和GM-CSF水平,同时观测鼻息肉组织中嗜酸粒细胞的浸润程度.以行鼻中隔手术患者中鼻甲粘膜作为对照.结果鼻息肉组织中IL-5,GM-CSF水平均明显高于中鼻甲组织(P<0.05),且两者含量分别与组织中的嗜酸粒细胞数呈正相关(前者r=0.75,后者r=0.71).结论提示IL-5,GM-CSF存在于鼻息肉组织的微环境中,它们对鼻息肉中嗜酸粒细胞的聚集起重要作用.

Concentration of interleukin-5 and granulocyte-macrophage colony stimulation factor in nasal polyps tissue and its significance

Objective To study the relationship between the concentration of interleukin 5 (IL 5) and granulocyte macrophage colony stimulation factor (GM CSF) in nasal polyps and its significance Methods The concentration of IL 5, GM CSF was measured by enzyme linked immunosorbent assay (ELISA) in a total of 38 cases, and the number of eosinophils were counted in the same tissues Results The statistical analysis showed that the concentrations of IL 5 and GM CSF have significant difference ( P <0 05) between the nasal polyps and the control group There is a positive correlation between the quality of IL 5/GM CSF and the extent of eosinophilis( r =0 75/0 71) Conclusion This study demonstrated that there are inductive compartments, namely the microenvironment, in which immune effector and inflammatory cell function is modulated in nasal polyps A special discussion has been made of eosinophils and IL 5 / GM CSF in the formation of nasal polyps, and the effect of the IL 5/GM CSF in the accumulation of eosinophils