Morphologic phenotyping with MR microscopy: the visible mouse |
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| Authors: | Johnson G Allan Cofer Gary P Gewalt Sally L Hedlund Laurence W |
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| Affiliation: | Center for In Vivo Microscopy, Duke University Medical Center, Rm 141, D Bryan Neuroscience Bldg, Research Dr, Durham, NC 27710, USA. gaj@orion.mc.duke.edu |
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| Abstract: | A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype. |
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