两种方案治疗早期梅毒患者血清学变化的研究

目的观察头孢曲松钠联合苄星青霉素治疗早期梅毒的临床效果及血清学效果。方法103例早期梅毒患者被随机分成治疗（n=57）和对照组（n=46）。治疗组采用头孢曲松钠2g／d连用10-15d，同时联合苄星青霉素240万u，1次／wk，共用2-3次；对照组应用苄星青霉素240万u，1次／wk，共用2-3次。结果治疗组血清学试验（TRUST）阴转率达100％，平均阴转时间5．6d；对照组血清学试验（TRUST）阴转率88．3％，平均阴转时间9．7d，两组差异显著（P〈0．05和P〈0．001）。结论苄星青霉素联合头孢曲松钠治疗早期梅毒疗效高并能显著缩短梅毒血清阴转时间。

Observation on the seriological changes of early congenital syphilis patients treated with combination of ceftriaxone sodium and bicillln

Objective To observe clinical sigmificamce of treatment of early congenital syphilis pateints with ceftriaxone sodium and bicillin in combination. Methods There 113 patients with early congenital syphilis were divided randomly into the study group consisted of 57 cases and the control group consisted of 46 cases. The study group were treated with 2g of ceftriaxone sodium by venous injection for 10 or 15 days and 2.4 milliom units of Bicillin by intramuscular injection once per week for 2 or 3 times ,while the control group were only treated with bicillin by intramuscular injection once per week for 2 or 3 times. Results The rate and the average time of TRUST negative conversion in the study group were 100% and 4. 0 months respectively, while that of the contol group were 88.3% and 9.6 months respectivedly, showing sigificant differences between two groups （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Combined use of ceftriaxone sodium and bicillin for treatment of patients with early congenital syphilis can apparently shorten the time of TRUST negative conversion.