| 奈达铂联合氟尿嘧啶治疗晚期食管癌83例疗效观察 |
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| 引用本文： | 冷祝强.奈达铂联合氟尿嘧啶治疗晚期食管癌83例疗效观察[J].中国医药指南,2011,9(12):21-23. |
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| 作者姓名： | 冷祝强 |
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| 作者单位： | 岳阳市中医院,湖南,岳阳,414000 |
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| 摘 要： | 目的观察奈达铂(NDP)联合氟尿嘧啶(5-FU)治疗晚期食管癌的近期疗效和不良反应。方法将117例晚期食管癌患者分为3组,初治患者86例,NDP治疗A组52例,给予NDP联合5-FU治疗;顺铂(DDP)对照组34例给予DDP联合5-FU治疗;NDP治疗B组为经DDP治疗失败的31例复治患者,给予NDP单药治疗,每28d重复为1周期。2~3周期为1个疗程。化疗2周期后按WHO标准进行评价。结果共入组117例,均可以进行疗效评价,NDP治疗组和DDP对照治疗组的疗效接近,分别为51.92%和47.06%;经DDP治疗失败的复治患者有效率为25.81%;NDP治疗A组中骨髓抑制所致的血小板减少、白细胞减少的发生率较高,DDP对照组中恶心呕吐发生率较高,两组差异显著(P<0.05)其他的不良反应两组相似。结论 NDP治疗晚期食管癌近期疗效与DDP接近,对DDP治疗失败的病例仍有一定疗效,其不良反应主要是骨髓抑制所致的血小板减少,白细胞减少。
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| 关 键 词： | 奈达铂 顺铂 氟尿嘧啶 食管癌 |
Nedaplatin Combined with Fluorouracil Treatment of Advanced Esophageal Cancer 83 Cases Observed |
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| LENG Zhu-qiang.Nedaplatin Combined with Fluorouracil Treatment of Advanced Esophageal Cancer 83 Cases Observed[J].Guide of China Medicine,2011,9(12):21-23. |
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| Authors: | LENG Zhu-qiang |
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| Institution: | LENG Zhu-qiang (Traditional Chinese Medicine Hospital of Yueyang,Yueyang 414000,China) |
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| Abstract: | Objective To nedaplatin(NDP) combined with fluorouracil(5-FU) chemotherapy in advanced efficacy and side effects.Methods117 patients with advanced esophageal cancer patients were divided into three groups,86 cases of newly diagnosed patients,NDP treatment A group of 52 cases,to give NDP combined 5-FU treatment;cisplatin(DDP) DDP control group of 34 patients were treated with combined 5-FU treatment;NDP treatment group B treated by DDP 31 patients with treatment failure in patients given monotherapy NDP,repe... |
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| Keywords: | Nedaplatin Cisplatin Fluorouracil Esophageal cancer |
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