New approaches to analysis of the interrelationship between cholinergic and dopaminergic mediator systems |
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| Authors: | Podosinovikova N P Kosmachev A B Tonkopiĭ V D Zagrebin A O Evdokimova E A Maslov A M Petrov V V Dolgo-Saburov V B |
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| Affiliation: | Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia. |
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| Abstract: | Intermediatory relationships between the cholinergic and dopaminergic neurotransmission systems were analyzed using published data and the original experimental results obtained on Daphnia magna Straus, a new test object. Based on these results, the antihaloperidol activity of a series of M- cholinoblocking agents with different receptor selectivities were studied in comparison to the new cholinoblocker pentifin exceeding in the activity the classical antiparkinsonian drugs such as cyclodol, amedin, and norakin. |
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