Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination. |
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| Authors: | K R Lottenbach C M Mink S J Barenkamp E L Anderson S M Homan D C Powers |
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| Affiliation: | Department of Internal Medicine and Center for Vaccine Development, Saint Louis University, St. Louis, Missouri, USA. lottenkr@slu.edu |
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| Abstract: | Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups. |
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