三维适形放疗联合GP方案化疗治疗局部晚期胰腺癌的临床观察

目的 分析三维适形放疗(3-DCRT)联合GP方案化疗治疗局部晚期胰腺癌的临床疗效.方法 40例局部晚期胰腺癌随机分为2组,治疗组22例给予3-DCRT联合GP方案化疗,对照组18例仅给予3-DCRT,治疗结束后评价临床疗效和毒副反应.结果 治疗组和对照组中位生存期分别为15个月和7个月,差异有统计学意义(P＜0.05).治疗组6个月和12个月生存率分别为86.4％、68.2％,高于对照组的50.0％、33.3％,差异有统计学意义(P均＜0.05).主要毒副反应为胃肠道反应和骨髓抑制,但均较轻.结论 3-DCRT联合GP方案化疗治疗局部晚期胰腺癌安全有效.

The Clinical Observation of Three-Dimensional Conformal Radiotherapy Combined with GP Regimen Chemotherapy in the Treatment of Locally Advanced Pancreatic Cancer

Objective To observe the clinical efficacy of three-dimensional conformal radiotherapy(3-DCRT) combined with GP regimen chemotherapy in the treatment of patients with locally advanced pancreatic cancer. Methods The 40 patients with locally advanced pancreatic cancer were randomly divided into two groups:the 22 patients in the therapy group received 3-DCRT combined with GP regimen chemotherapy,the 18 patients in the control group received 3-DCRT alone.The clinical efficacy and the toxicities were observed after the treatment. Results The median survival time was 15 months in the therapy group,and was 7 months in the control group(P<0.05).The 6 and 12 month survival rates were respectively 86.4% and 68.2% in the therapy group,and were respectively 50.0% and 33.3% in the control group(P<0.05).The main toxicities were gastrointestinal reaction and marrow suppression. Conclusion 3-DCRT combined with GP regimen chemotherapy is effect and safe for the patients with locally advanced pancreatic cancer.