吲哚布芬联合氯吡格雷治疗不稳定型心绞痛疗效观察

目的 探讨吲哚布芬联合氯吡格雷治疗不稳定型心绞痛的临床疗效.方法 对入选的68例患者随机分为观察组和对照组各34例,观察组给予吲哚布芬和氯吡格雷,对照组给予阿司匹林和氟吡格雷,进行4周的观察.对两组治疗前后的心绞痛次数与持续时间、临床疗效、安全性进行比较.结果 与治疗前相比心绞痛发作次数和持续时间均有明显下降(P＜0.05),两组间临床疗效比较无明显差异(P＞0.05),观察组的安全性明显优于对照组.结论 吲哚布芬与氯吡格雷联合使用治疗不稳定型心绞痛临床疗效与阿司匹林联用氯吡格雷相当,具有更好的安全性.

Clinic Analysis of Treatment on the unstable angina pectoris with Indobufen and clopidogrel

Objective To investigate the effects and safety of Xinbei-indobufen and clopidogrel in patients with unstable angina pectoris.Methods 68 patients were randomly divided into experiment group(n=34) and control group(n=34).The patients in experiment group were given anti-platelet indobufen and clopidogrel,in control group were given aspirin and clopidogrel for 4 weeks.The frequency and duration of unstable angina pectoris were compared between pre and post treatment.The clinical efficacy and safety were compared between experiment group and control group.Results After treatment,the frequency and duration of unstable angina pectoris in both groups were lower than before(P<0.05).The overall curative effects were similar in patients of the two groups(P>0.05).But the experiment group was safe then control group.Conclusion The clinical efficacy were similar in patients with unstable angina pectoris between Xinbei-indobufen、clopidogrel and aspirin、clopidogrel,but the aspirin and clopidogrel was more safe.