98例脑转移癌放疗疗效分析

目的 探讨全脑放疗在脑转移癌姑息性治疗中的疗效.方法 98例脑转移癌姑息性全脑放疗患者根据放疗分割方式的不同分为3组,均选用6 MV-X线全脑照射,每天1次,每周5次.A组45例:DT40Gy/20次/4周；B组20例:DT 30 Gy/15次/3周；C组23例:DT 30 Gy/10次/2周.分析不同分割方式全脑放疗后患者的生存情况.结果 A组、B组、C组的总有效率分别为97.8％、95.0％、95.7％ (P ＞0.05).A组、B组、C组的中位生存期分别为11.5、11.0、10.8个月；1a生存率分别为40.0％、30.0％、34.8％(P＞0.05)；2 a生存率分别为11.1％、10.0％、8.7％(P＞0.05).3组患者的KPS评分比较差异无统计学意义(P＞0.05).结论 全脑放疗对脑转移癌患者疗效较好,毒副反应轻,其中DT30 Gy/10次/2周的分割方式较其他2种方式具有节约医用资源的优势.

The Analysis of Whole Brain Radiotherapy of 98 Patients with Intracranial Metastases

Objective To study the effect of whole brain radiotherapy in the treatment of intracranial metastases. Methods According to the time-dosage fractionation regimen,98 patients were divided into three groups,and received 6 MV-X ray radiotherapy,1 time/d,5 times/week.Forty five patients in the A group: DT 40 Gy/20 times/4 weeks;20 patients in the B group: DT 30 Gy/15 times/3 weeks;23 patients in the C group: DT 30 Gy/10 times/2 weeks. Results The response rates were 97.8%,95.0% and 95.7% in the A group,the B group and the C group(P>0.05).The median survival time of the A group,the B group,the C group were 11.5,11.0 and 10.8 months;the 1-year survival rates were 40.0%,30.0% and 34.8%(P>0.05);the 2-year survival rates were 11.1%,10.0% and 8.7%(P>0.05).There was no statistic difference in the KPS scores among the three groups(P>0.05). Conclusion The whole brain radiotherapy is effective for the patients with intracranial metastases,the regimen of the C group(DT 30 Gy/10 times/2 weeks) can save medical resources.