Parameters of high-density lipoproteins in patients with arterial hypertension in combination with other components of metabolic syndrome |
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Authors: | I N Ozerova N V Perova N V Shchel’tsyna M N Mamedov |
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Institution: | (1) Department of Metabolic Disorders, State Research Center for Preventive Medicine, Federal Agency on Health Care and Social Development, Moscow |
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Abstract: | Parameters of HDL (concentrations of cholesterol, apoprotein A1, and phospholipids and phospholipid composition) determining
their functional properties were studied in patients with arterial hypertension in combination with other components of metabolic
syndrome (abdominal obesity, hyperlipidemia, and impaired glucose tolerance). Patients with isolated arterial hypertension
did not differ from the control group by the concentration of apoprotein A1 and HDL cholesterol, but had lower content of
HDL phospholipids and changed phospholipid composition: lower ratio of phosphatidylcholine and higher relative contents of
lysophosphatidylcholine, sphingomyelin, and phosphatidylethanolamine. Parameters of HDL in patients with arterial hypertension
associated with other components of metabolic syndrome did not differ from those in patients with isolated arterial hypertension.
The observed changes in HDL in patients with arterial hypertension alone or in combination with other components of metabolic
syndrome can impair functional capacity of HDL in reverse cholesterol transport, which increases the risk of atherosclerosis.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 3, pp. 289–292, March, 2007 |
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Keywords: | high-density lipoproteins phospholipids apoprotein A1 arterial hypertension metabolic syndrome |
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