地卓西平马来酸盐动物行为模型研究

目的 制作灵长类动物从氨酸Ｎ－甲基－天冬氨酸受体非竞争性拮抗剂地产马来酸盐（ＭＫ－８０１）功能低下行为模型：研究奥氮平治疗谷氨酸功能低下的疗效。方法：给Ｃｅｂｕｓ Ａｐｅｌｌａ猴皮下注射ＭＫ－８０１（０．０６ｍｇ／ｋｇ，０．０８ｍｇ／ｋｇ，０．１０ｍｇ／ｋｇ）或／和奥氮平（０．０２ｍｇ／ｋｇ，０．０４ｍｇ／ｋｇ，０．０８ｍｇ／ｋｇ），用自编７分量表评定药物所致动物的行为变化。结果 注射药物３ｈ内动

Research on the behavioral animal model of dizolcipine maleate

s Objectives The study was to study the glutamate deficiency model in Cebus Apella and the efficacy of atypical antipsychotics olanzapine in treating the glutamate deficiency model in six Cebus Apella monkeys Methods Dizolcipine maleate (MK 801,0 06, 0 08 and 0 10 mg/kg), as the non competitive NMDA receptor antagonist, and the atypical antipsychotic, olanzapine (0 02, 0 04 and 0 08 mg/kg), were administrated by subcutaneously injection A 7 scores scale was used to evaluate the behaviors of animal before and after the drug injection Results Animals with low dose of MK 801 experienced decreased locomotion (3 29), bradyskinesia (3 25) and dystonia in two of animals Low and middle dose olanzapine had no effect on these abnormal behaviors, while high dose antagonized effectively or completely these behaviors Middle and high dose MK 801 induced severe dystonia (4 45, 4 08), decreased locomotion (4 63, 4 5) and bracyskinesia (4 63, 4 33) High dose olanzapine reversed partly these behaviors of high dose MK 801(2 67, 2 92 and 2 92) By the way, olanzapine had no any effect on salivation, while, exacerbating ataxia of MK 801 Conclusions Similar to Phencyclide, MK 801 is another useful tool of psychopharmacologic model for evaluation the effects and adverse effects of antipsychotics Olanzapine, an atypical antipsychotics, is able to antagonize the abnormal behaviors induced by glutamate deficiency, which means its potiential clinical profile in clinical practice