| 持久性有机污染物和《斯德哥尔摩公约》履约 |
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| 引用本文： | 常思思, 姚谦, 田英, 徐文玺, 施蓉. 全氟化合物暴露对婴幼儿甲状腺激素水平影响的研究进展[J]. 上海预防医学, 2019, 31(9): 773-777, 783. DOI: 10.19428/j.cnki.sjpm.2019.19488 |
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| 作者姓名： | 常思思 姚谦 田英 徐文玺 施蓉 |
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| 作者单位： | 1.上海交通大学公共卫生学院，上海 200025;2.上海市东方医院，上海 200120 |
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| 基金项目： | 国家自然科学基金面上项目(81872629);上海市自然科学基金面上项目(19ZR1428900);上海交通大学“医工交叉”基金面上项目(YG2017MS84);上海市黄浦区科委课题项目(HKW201525) |
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| 摘 要： | 全氟化合物(per-and polyfluoroalkyl substances，PFASs)是一种新型的持久性有机污染物，由于其广泛使用，越来越多地区的环境介质中被检测出PFASs。PFASs具有多种毒性效应，其中甲状腺毒性备受关注。研究认为PFASs可通过干扰人体的甲状腺激素水平，进而影响人体的正常生理机能，尤其是婴幼儿的生长发育。本文综述了PFASs的环境暴露浓度对人群尤其是婴幼儿的甲状腺激素水平影响的研究进展，大量文献表明母亲血清或脐带血清中的PFASs水平与脐带血清或婴幼儿血样中的甲状腺激素水平有关，该现象为揭示PFASs对易感人群的甲状腺激素水平影响及机制提供参考依据。
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| 关 键 词： | 全氟化合物 甲状腺激素 婴幼儿 流行病学研究 |
| 收稿时间： | 2019-04-10 |
Detection of poly- and perfluoroalkyl substances (PFASs) in U.S.drinking water linked to industrial sites,military fire training areas,and wastewater treatment plants |
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| CHANG Si-si, YAO Qian, TIAN Ying, XU Wen-xi, SHI Rong. Research progress in per- and polyfluoroalkyl substances(PFASs) exposure and level of thyroid hormones in infants and children[J]. Shanghai Journal of Preventive Medicine, 2019, 31(9): 773-777, 783. DOI: 10.19428/j.cnki.sjpm.2019.19488 |
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| Authors: | CHANG Si-si YAO Qian TIAN Ying XU Wen-xi SHI Rong |
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| Affiliation: | 1.School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China;2.Shanghai Oriental Hospital, Shanghai 200120, China |
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| Abstract: | Per- and polyfluoroalkyl substances (PFASs), a new type of persistent organic pollutants, have been detected in various environmental media due to their widespread use.PFASs possess a variety of toxic effects, and the thyroid toxicity is of great concern.Studies suggest that PFASs can interfere with the body′s thyroid hormone levels, thus affecting normal physiological functions, especially growth and development of infants and children.This paper is a review of advances in research of the relation between environmental exposure concentration of PFASs and thyroid hormones levels in population, especially in infants and children, and a large number of literature have shown that PFASs levels in maternal serum or umbilical cord serum are related to thyroid hormone levels in umbilical cord serum or infant blood samples.This phenomenon provides references for exploring the effect and mechanism of PFASs on the level of thyroid hormones among the susceptible population. |
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| Keywords: | per- and polyfluoroalkyl substances thyroid hormones infants epidemiologic studies |
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