| 2-巯基-5-甲氧基苯并咪唑合成工艺的研究 |
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| 引用本文： | 陈志明. 2-巯基-5-甲氧基苯并咪唑合成工艺的研究[J]. 中国现代应用药学, 2006, 0(Z1) |
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| 作者姓名： | 陈志明 |
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| 作者单位： | 浙江富盛控股集团有限公司研发中心 浙江常山324200 |
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| 摘 要： | 目的改进2-巯基-5-甲氧基苯并咪唑的合成工艺。方法以对氨基苯甲醚为起始原料,采用醋酸硝酰作硝化剂进行硝化;采用雷尼镍催化加氢法进行还原。结果制得了奥美拉唑中间体2-巯基-5-甲氧基苯并咪唑,总收率78.5%。结论值得推广到工业化生产。
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| 关 键 词： | 奥美拉唑 2-巯基-5-甲氧基苯并咪唑 雷尼镍 催化加氢 醋酸硝酰 |
Study on Synthesis of 2-Mercapto-5-Methoxybenzimidazole |
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| CHEN Zhi-ming. Study on Synthesis of 2-Mercapto-5-Methoxybenzimidazole[J]. The Chinese Journal of Modern Applied Pharmacy, 2006, 0(Z1) |
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| Authors: | CHEN Zhi-ming |
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| Abstract: | OBJECTIVE To improve the synthetic process of 2-Mercapto-5-Methoxybenzimidazole(1).METHODS Product(1) was synthesized from p-aminoanisole by acetylation,nitrification,hydrolysis,reduction and cyclic condensation.The nitrifying agent was nitroxyl acetate,and Ranney nickel was used as catalyst. RESULTS Totle yield was up to 78.5%.CONCLUSION It's deserved to be pushed to comercial scale production. |
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| Keywords: | Omeprazole 2-Mercapto-5-Methoxybenzimidazole Ranney nickel catalytic hydrogenation nitroxyl acetate |
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