| 安徽省早期甲型H1N1流感病毒的血凝素基因序列分析 |
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| 引用本文： | 何军,孙永,王俊,史永林,胡万富,马明英,刘丽萍.安徽省早期甲型H1N1流感病毒的血凝素基因序列分析[J].安徽预防医学杂志,2010,16(2):85-86,95. |
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| 作者姓名： | 何军 孙永 王俊 史永林 胡万富 马明英 刘丽萍 |
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| 作者单位： | 安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061;安徽省疾病预防控制中心,安徽,合肥,230061 |
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| 摘 要： | 目的检测、分析安徽省甲型H1N1流感早期病例的病毒血凝素（HA）基因的序列特征。方法RT-PCR方法扩增我省早期流感样病例的病毒核酸并对其HA基因序列进行分析比对。结果我省早期甲型H1N1流感病例的病毒HA基因与2009年全球流行的甲型H1N1流感病毒高度同源,与古典型猪流感亲缘性较近,与欧洲和亚洲分离的A/H1N1猪流感和A/H1N1禽流感亲缘关系较远。结论我省早期流行的甲型H1N1流感毒株HA基因可能由古典型猪流感进化而来,与WHO选定的甲型H1N1疫苗候选株同源性较高,对于人季节性流感A/H1N1疫苗可能并不敏感。
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| 关 键 词： | 甲型H1N1流感病毒 RT-PCR 血凝素基因 序列分析 |
Sequence Analysis of Hemagglutinin Gene of Influenza A/H1N1 Virus from Cases in The Early Stage of Disease Cowse in AnHui Province |
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| HE Jun,SUN Yong,WANG Jun,SHI Yong-lin,HU Wan-fu,MA Ming-ying,LIU Li-ping.Sequence Analysis of Hemagglutinin Gene of Influenza A/H1N1 Virus from Cases in The Early Stage of Disease Cowse in AnHui Province[J].Anhui Journal of Preventive Medicine,2010,16(2):85-86,95. |
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| Authors: | HE Jun SUN Yong WANG Jun SHI Yong-lin HU Wan-fu MA Ming-ying LIU Li-ping |
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| Institution: | Anhui Provincial Center for Disease Control and Prevention;Hefei;Anhui 230061;China |
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| Abstract: | Objective To analyze the sequence characteristic of hemagglutinin gene(HA) of influenza A/H1N1 virus from cases in the early stage in AnHui Province.Methods Influenza A/H1N1 Virus DNA of cases in an early stage was amplified by RT-PCR,and sequences of HA were then analyzed and compared.Results Sequences of HA of influenza A/H1N1 virus in the early stage in AnHui Province was homologous with sequence of influenza H1N1 virus circulated in 2009 around the world,was more closely related to classical swine influ... |
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| Keywords: | Influenza A/H1N1 Virus RT-PCR Hemagglutinin Gene Sequence Analysis |
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