Simple limbal epithelial transplantation: a review on current approach and future directions |
| |
| Authors: | Davide Borroni Bogumil Wowra Vito Romano Maria Boyadzhieva Diego Ponzin Stefano Ferrari Sajjad Ahmad Mohit Parekh |
| |
| Affiliation: | 1. Department of Ophthalmology, Riga Stradins University, Riga, Latvia;2. Department of Genetics, Riga Stradins University, Riga, Latvia;3. Department of Ophthalmology, Medical University of Silesia, Katowice, Poland;4. Department of Corneal and External Eye Diseases, St Paul''s Eye Unit, Royal Liverpool University Hospital, Liverpool, UK;5. Department of Eye and Vision Science, University of Liverpool, Liverpool, UK;6. Department of Ophthalmology, Medical University of Varna, Varna, Bulgaria;7. International Center for Ocular Physiopathology, The Veneto Eye Bank Foundation, Venice, Italy;8. Moorfields Eye Hospital NHS Foundation Trust, London, UK;9. University College London Institute of Ophthalmology, London, UK |
| |
| Abstract: | Simple limbal epithelial transplantation is a recently developed technique for treating limbal stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is atttached using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. The limbal biopsy pieces are placed onto the amniotic membrane, fixed with fibrin glue, followed by bandaging of the ocular surface with a contact lens. This technique (auto simple limbal epithelial transplantation) offers easier surgical manipulations and economic advantages over other techniques for the treatment of limbal stem cell deficiency. We therefore review simple limbal epithelial transplantation along with recent modifications in the technique and case studies, including challenges and failures. |
| |
| Keywords: | LSCD limbal cells amniotic membrane SLET transplant |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
