小剂量沙利度胺治疗骨髓增生异常综合征21例疗效观察

目的:观察小剂量沙利度胺治疗骨髓增生异常综合征(MDS)的疗效与不良反应。方法:沙利度胺联合雄激素及维甲酸治疗MDS 21例,其中低危患者(RA/RARS)12例,高危患者(RAEB)9例。结果:总有效率47.6%;12例低危患者中6例获得血液学进步(HI),有效率50.0%;9例高危患者中1例完全缓解(CR),1例部分缓解(PR),2例血液学进步,两组有效率差异无统计学意义(P>0.05)。所有接受沙利度胺治疗的21例患者,8例获血液学进步,其中HI-E 6例,HI-P 4例,HI-N 3例。无明显不良反应。结论:小剂量沙利度胺治疗骨MDS疗效肯定,尤其对那些依赖红细胞输注的MDS的患者疗效明显,副作用小,可作为治疗MDS首选的单一或联合用药。

Efficacy of low-dose thalidomide on myelodysplastic syndrome:Report of 21 cases

Objective:To observe the effect and side-effect of low-dose thalidomide in treatment for myelodysplastic syndromes(MDS).Methods:Twelve cases of low-risk MDS(RA/RARS)and 9 cases of high-risk MDS(RAEB)were treated by combined therapy of thalidomide,androgen and retinoic acid.Results:The total response rate was 47.6%.In the low-risk MDS group,hematological improvement(HI)was observed in 6 cases,with an effective rate of 50.0%;in the high-risk MDS group,complete remission(CR)was achieved in 1 case,partial remis...