碱性成纤维细胞生长因子对兔血管舒张功能及左旋精氨酸/一氧化氮途径的影响

目的：本文观察了碱性成纤维细胞生长因子（ｂＦＧＦ）对离体主动脉舒张反应，一氧化氮（ＮＯ）生成及左旋精氨酸（Ｌ－Ａｒｇ）转运的影响。方法：离体大鼠主动脉环测定张力，主动脉薄片孵育测定ＮＯ生成和Ｌ－精氨酸（Ｌ－Ａｒｇ）转运。结果：ｂＦＧＦ呈剂量依赖性地诱导血管内皮依赖性舒张，增加血管低亲和Ｌ－Ａｒｇ的最大转运速度（与对照组比较增加４５％，Ｐ＜０．０１），显著增加ＮＯ的产生（比对照组增加４３％）。结论：ｂＦＧＦ可增加Ｌ－Ａｒｇ转运，对内皮衍生舒张因子／一氧化氮（ＥＤＲＦ／ＮＯ）系统具有重要的调节作用

The effects of basic fibroblast growth factor on aortic relaxation and L-arginine/nitric oxide system

AIM:To study the effects of basic fibroblast growth factor (bFGF) on aortic relaxation, nitric oxide(NO) production, and L-arginine(L-Arg) transport of rabbit in vitro . METHODS:Vascular tone was measured with bath of isolated rat aortic ring. NO formation and L-arginine transport were assayed by aortic slice incubation. RESULTS:bFGF could induced endothelium-dependent aortic relaxation in dose dependent manner. When incubated with bFGF, aortic slices could produce NO about 43% more than that of control group, and the maximal viscosity of low affinity L-Arg transport was promoted by bFGF. CONCLUSION:bFGF might affect L-Arg/NO system to different extents.