| Dkk-Wnt信号通路在牙齿发育中作用的研究进展 |
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| 引用本文： | 吴也可,韩向龙,白丁.Dkk-Wnt信号通路在牙齿发育中作用的研究进展[J].牙体牙髓牙周病学杂志,2012(5):298-301. |
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| 作者姓名： | 吴也可 韩向龙 白丁 |
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| 作者单位： | 四川大学口腔疾病研究国家重点实验室;四川大学华西口腔医院正畸科 |
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| 基金项目： | 国家自然科学基金资助(31000419,11172190);四川省科技厅科技支撑项目(2010SZ0174) |
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| 摘 要： | 哺乳动物的牙齿发育是外胚层上皮与间充质间相互调控和信号交流的结果,其中Dkk-Wnt信号通路是近年来牙胚发育研究领域的热点。Dkk-Wnt信号通路已被证实在牙体形成细胞功能的发挥、牙齿模式化、形态发生、牙冠钙化过程中扮演重要作用。牙齿发生发育分子机制的深入研究,将为牙再生组织工程技术以及相关技术的临床转化提供理论基础。本文就近十年对Wnt信号通路在牙齿发育中所起作用的研究作一综述。
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| 关 键 词： | Wnt Dkks 牙齿发育 牙模式化 形态发生 |
Research progress on the role of Dkk-Wnt signaling pathway on tooth development |
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| WU Ye-ke,HAN Xiang-long,BAI Ding.Research progress on the role of Dkk-Wnt signaling pathway on tooth development[J].Chinese Journal of Conservative Dentistry,2012(5):298-301. |
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| Authors: | WU Ye-ke HAN Xiang-long BAI Ding |
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| Institution: | (State Key Laboratory of Oral Diseases,Department of Orthodontics, West China School of Stomatology,Sichuan University,Chengdu 610041,China) |
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| Abstract: | Mammalian tooth development is largely dependent on the sequential and reciprocal epithelial-mesenchymal interaction.Dkk-Wnt signaling pathway has become a hot point in the research field of tooth development.Dkk-Wnt signaling is proved to be critical in the process of tooth-forming cells functioning,tooth patterning,tooth morphogenesis and crown calcification.Elucidation of molecular mechanisms involved in tooth development will surely provide theoretical basis for translational clinical application of tissue engineering strategies such as tooth regeneration.This article is committed to review on the research progress regarding the role of Wnt signaling pathway on tooth development in recent years. |
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| Keywords: | Wnt dkks tooth development tooth patterning morphogenesis |
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