桥本氏病患者心理健康状况及社会功能的影响因素

目的 研究桥本氏病(HT)患者心理健康状况及社会功能的影响因素.方法 应用90项症状清单(SCL-90)、社会功能缺陷筛选量表,评定HT患者治疗前后心理健康状态、社会功能的改变及影响因素.结果 HT组SCL-90总均分、躯体化、人际关系敏感、抑郁、焦虑、社会功能缺陷评分分别为(1.7±0.6)分,(2.0±0.7)分,(1.9±0.6)分,(2.0±0.6)分,(1.8±0.5)分,(5.2±0.9)分]高于对照组分别为(1.4±0.4)分,(1.3±0.5)分,(1.6±0.5)分,(1.5±0.6)分,(1.4±0.4)分,(1.3±0.8)分](P<0.01).HT患者经左旋甲状腺素(L-T4)治疗3月后SCL-90总均分、躯体化、人际关系敏感、抑郁、焦虑及社会功能缺陷评分分别为(1.3±0.5)分,(1.5±0.5)分,(1.6±0.4)分,(1.6±0.4)分,(1.4±0.6)分,(1.8±0.3)分]明显下降(P<0.01),其中HT患者经治疗后社会功能缺陷评分仍高于正常组(t=5.78,P<0.01).Logistic回归分析示影响HT患者SCL-90总均分危险因素为社会功能缺陷评分(F=1.16,P<0.01)、TSH(F=2.05,P<0.01)及TPO(F=3.48,P<0.01).结论 HT患者存在心理健康及社会功能问题,TSH、TPO为危险因素,L-T4补充治疗利于心理健康及社会功能的恢复.

The influencing factors of psychological health status and social disability in hashimoto thyroiditis

Objective To analyze of the influencing factors of mental health status and social disability for hashimoto thyroiditis(HT) patients.Methods The research employed Symptom Checklist 90 (SCL-90) and Social Disability Screening Schedule (SDSS) to evaluate the change and the influencing factors of mental health status and social disability of Hashimoto Thyroiditis patients.Result The scores of SCL-90 share,body symptom,sensitiveness relationship,depression,anxiety and social disability (1.7±0.6),(2.0±0.7),(1.9±0.6),(2.0±0.60),(1.8±0.5) and (5.2±0.9),respective] in HT were increased compared with normal group(1.4±O.4),(1.3±O.5),(1.6±O.5),(1.5±0.6),(1.4±0.4),(1.3±0.8) respective](P<0.01).In HT subjecte receiving levothyroxine(L-T4) therapy for 3 months,the scores of SCL-90 share score,body symptom,sensitiveness relationship.depression,anxiety and social disability were reduced respectively by(1.3±0.5),(1.5±0.5),(1.6±0.4),(1.6±0.4),(1.4±0.6) and(1.8±0.3)(all P<0.01).At the same time,the score of social disabilitv after therapy was increased compared with normal group (t=5.78,P<0.01).With the Logistic analyses.the score of social disability(F=1.16,P<0.01),TSH (F=2.05,P<0.01) and TP0(F=3.48.P<0.01)were risk factors of SCL-90 share score in HT subjects.Conclusion There were psychological health symptoms and social disability in HT case.TSH and TPO were risk factors of psychological health.L-T4Wag good for returning to normal mood.