| 受精促进肽对哺乳动物精子受精能力的促进作用研究进展 |
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| 引用本文： | 马用信,张思仲.受精促进肽对哺乳动物精子受精能力的促进作用研究进展[J].中华医学遗传学杂志,2003,20(2):151-155. |
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| 作者姓名： | 马用信 张思仲 |
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| 作者单位： | 610041,成都,四川大学华西医院医学遗传室 |
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| 基金项目： | 国家自然科学基金 (30 1 70 359)，国家“863”高科技计划(2 0 0 1AA2 1 60 91 )~~ |
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| 摘 要： | 受精促进肽和腺苷酸一起调控腺苷酸环化酶／cAMP信号通路，起初促进获得和随后抑制顶体的丢失，从而提高人及哺乳动物精子受精能力。现就受精促进肽在这一调控过程中的作用进行综述，并对其可能的作用机理进行讨论。
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| 关 键 词： | 受精促进肽 鼠Tcp11基因 腺苷环化酶 cAMP信号通路 |
| 修稿时间： | 2002年8月27日 |
Advances in modulation of mammalian sperm function by fertilization promoting peptide |
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| MA Yong xin,ZHANG Si zhong..Advances in modulation of mammalian sperm function by fertilization promoting peptide[J].Chinese Journal of Medical Genetics,2003,20(2):151-155. |
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| Authors: | MA Yong xin ZHANG Si zhong |
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| Institution: | Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. szzhang@mcwcums.com |
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| Abstract: | Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss by modulation of the adenylyl cyclase (AC)/cAMP signal transduction pathway. This is a review aimed at analyzing the function of fertilization promoting peptide during this process. The possible molecular basis is also discussed. |
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| Keywords: | fertilization promoting peptide mouse Tcp11 gene adenyl cyclase/cAMP signal transduction pathway |
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