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| 抗血吸虫药1-(5-硝基-2-噻吩亚甲氨基)咪唑烷-2-酮及其类似物的合成 | |
| 引用本文： | 马桢,黄兰荪. 抗血吸虫药1-(5-硝基-2-噻吩亚甲氨基)咪唑烷-2-酮及其类似物的合成[J]. 中国医药工业杂志, 1993, 0(4) |
| 作者姓名： | 马桢 黄兰荪 |
| 作者单位： | 中国预防医学科学院寄生虫病研究所 上海200025 |
| 摘 要： | 1-(5-硝基-2-噻吩亚甲氨基)-咪唑烷-2-酮(1)具有抗曼氏血吸虫作用。考虑其结构与硝唑咪相似,推测该化合物可能也具有抗日本血吸虫作用,故合成了该化合物及其类似物。药理筛选证明,1确有较显著的抗日本血吸虫作用。 |
| 关 键 词： | 抗血吸虫药 1-(5-硝基-2-噻吩亚甲氨基)咪唑烷-2-酮 1-取代亚甲氨基咪唑烷-2-酮 1-取代亚甲氨基-4-甲基哌嗪 合成 |
SYNTHESIS OF 1-(5-NITRO-2-THIENYLIDENEAMINO)-2-IMIDAZOLIDONE AND ITS ANALOGS AS SCHISTOSOMICIDES |
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| MA Zhen HUANG Lan-Sun. SYNTHESIS OF 1-(5-NITRO-2-THIENYLIDENEAMINO)-2-IMIDAZOLIDONE AND ITS ANALOGS AS SCHISTOSOMICIDES[J]. , 1993, 0(4) | |
| Authors: | MA Zhen HUANG Lan-Sun |
| Abstract: | Effect of 1-(5-nitro-2-thienylideneamino)-2-imidazolidone(1)against Schistosoma mansoni in mice has been reported.Since the structure of 1 issimilar to that of niridazole possessing activity against S.japonicum in mice.1and its analogs were synthesized.Screening test showed that 1 had pronouncedactivity against S.japonicum in mice. |
| Keywords: | schistosomicide 1-(5-nitro-2-thienylideneamino)-2-imidazolidone 1-(substituted methyl eneamino)-2-imidazolidone 1-(substituted methyleneamino)-4-methylpiperazine synthesis |
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