| 新建人膀胱癌细胞系BIU-87的染色体分析 |
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| 引用本文： | 俞莉章,黄雅丽,宋莲芬,顾方六,张子娟,王戈华. 新建人膀胱癌细胞系BIU-87的染色体分析[J]. 北京大学学报(医学版), 1990, 0(2) |
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| 作者姓名： | 俞莉章 黄雅丽 宋莲芬 顾方六 张子娟 王戈华 |
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| 作者单位： | 北京医科大学泌尿外科研究所(俞莉章，黄雅丽，宋莲芬，顾方六)，江西九江医学专科学校(张子娟)，北京医科大学生物学教研室(王戈华) |
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| 摘 要： | 新建的人膀胱癌细胞系命名为BIU-87,本文研究其染色体及其G带的变化及临床意义。BIU-87细胞有明显的超4倍体特点,分析100个中期细胞得出染色体众数平均为101条。染色体形态结构与正常细胞相比有很大不同,可检出12个异常的标记染色体。其中最为明显的M_1和M_2标记染色体都与1号染色体有关。这将有助于临床辅助诊断膀胱癌。双小体的存在提示了细胞癌变和癌基因变化之间的关系。
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| 关 键 词： | BIU-87细胞系 染色体 超4倍体 标记染色体 |
CHROMOSOME STUDY ON A NEWLY ESTABLISHED HUMAN BLADDER CANCER CELL LINE BIU-87 |
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| Yu Lizhang Institute of Urology. CHROMOSOME STUDY ON A NEWLY ESTABLISHED HUMAN BLADDER CANCER CELL LINE BIU-87[J]. Journal of Peking University. Health sciences, 1990, 0(2) |
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| Authors: | Yu Lizhang Institute of Urology |
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| Affiliation: | Yu Lizhang Institute of Urology |
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| Abstract: | A newly established cell line, derived from human bladder carcinoma, was designated as BIU-87.Its chromosome G-banding karyotype and clinical implication were studed. The chromosome number ofthe BIU-87 was characterized as hetertetraploid. By analysing 100 mitosis cells, the modal count was101 and the structure was quite diffrent from that of normal cell. A total of 12 marker chromosomeswas discovered. Notably. the M 1 and M 2 marker chromosomes are related to No. 1 chromosome. Weconclude that it could be of help to dignosis of bladder carcinoma. The presence of some doubleminute (DM) may imply the relationship between malignant cell and the oncogene. |
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| Keywords: | Cell Line BIU-87 Chromosome Hyerptetraploid Marker |
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