Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression

Authors:	G?ran?Landberg,Kristina?Nilsson,Karin?Jirstr?m,Lisa?Rydén,Richard?Kitching,Angelika?M.?Burger,Arun?Seth author-information" > author-information__contact u-icon-before" > mailto:arun.seth@utoronto.ca" title=" arun.seth@utoronto.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Division of Pathology, Department of Laboratory Medicine, U-MAS, Lund University, Malmö, Sweden;(2) Department of Laboratory Medicine and Pathobiology, Laboratory of Molecular Pathology and Sunnybrook and Womens College Health Sciences Centre, University of Toronto, Toronto, Canada

Abstract:	Summary In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.

Keywords:	breast cancer cyclin I proliferation VEGF
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