不同类型急性脑卒中患者血清LPA表达及意义

目的探讨不同类型急性脑卒中患者血清溶血磷脂酸(LPA)变化及临床意义。方法 60例急性脑卒中患者分为出血性卒中组28例和缺血性卒中组32例。入院当天(发病7天内)以ELISA法测定60例急性脑卒中患者和30例健康体检者的血清LPA水平,所有患者采用中国卒中量表(CSS)进行临床神经功能缺损程度评分,分析急性脑卒中LPA水平与脑卒中各类型、初发/复发、神经功能缺损程度的关系。结果①急性脑卒中患者血清LPA水平明显高于对照组(P<0.05);缺血性卒中组患者血清LPA水平明显高于出血性脑卒中患者(P<0.05);②复发组脑卒中患者血清LPA水平比初发组明显增加(P<0.05);③急性脑卒中患者血清LPA水平随神经功能缺损CSS评分的增高而增高(P<0.05)。结论急性脑卒中患者血清LPA水平明显增高,尤其在缺血性脑卒中患者中更为明显,可作为判断脑卒中患者病情诊断、严重程度及再发风险的血液指标。

The Expression and Significance of LPA in the Patients with Different Types of Acute Stroke

Objective To explore the changes and clinical significance of serum LPA levels in the patients with different types of acute stroke. Methods 60 patients with acute stroke (group A) and 30 healthy volunteers (control group, group C) were recruited from Zhaoqing First People’s Hospital. The serum levels of LPA in group A and group C were detected on the 1 st day by enzyme-linked immunisorbent assay (ELISA), and all the patients were evaluated by Chinese Stroke Scale (CSS), to analyze the relations between the serum levels of LPA and the types of stroke, or first occurrence / recurrence or CSS. Results ①The serum level of LPA in group A was higher than that in group C (P <0.05); The serum level of LPA in ischemic stroke was higher than that in hemorrhagic stroke (P <0.05); ②The serum level of LPA in recurrence stroke was higher than that in first occurrence stroke (P <0.05); ③The serum level of LPA increased significantly with CSS (P <0.05). Conclusions The serum level of LPA increases after acute stroke, especially in ischemic strike, which may be a valuable index for diagnosis, severity, and stroke recurrrence.