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High-risk HPV infection after five years in a population-based cohort of Chilean women |
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| Authors: | Catterina Ferreccio Vanessa Van De Wyngard Fabiola Olcay M Angélica Domínguez Klaus Puschel Alejandro H Corvalán Silvia Franceschi Peter JF Snijders |
| Institution: | 1. Molecular Biology and Viral Oncology and AIDS Ref. Centre, National Cancer Institute “Fond. Pascale”, Naples, Italy 2. Hepato-biliary Surgery Department, National Cancer Institute, “Fond. Pascale”, Naples, Italy 3. Department of Pathology, National Cancer Institute, “Fond. Pascale”, Naples, Italy |
| Abstract: | BackgroundSingle-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Few studies have analysed the role of these polymorphisms in the development of hepatocellular carcinoma.MethodsGenotype distribution of TP53 codon 72 and MDM2 SNP309 in 61 viral hepatitis-related hepatocellular carcinoma cases and 122 blood samples (healthy controls) from Italian subjects were determined by PCR and restriction fragment length polymorphism (RFLP).ResultsFrequencies of TP53 codon 72 alleles were not significantly different between cases and controls. A significant increase of MDM2 SNP309 G/G and T/G genotypes were observed among hepatocellular carcinoma cases (Odds Ratio, OR = 3.56, 95% Confidence Limits, 95% CI = 1.3-9.7; and OR = 2.82, 95% CI = 1.3-6.4, respectively).ConclusionsThese results highlight a significant role of MDM2 SNP309 G allele as a susceptibility gene for the development of viral hepatitis-related hepatocellular carcinoma among Italian subjects. |
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