| 反相HPLC法同时测定普鲁卡因和利多卡因含量 |
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| 引用本文： | 王海峰,王然,唐晓东.反相HPLC法同时测定普鲁卡因和利多卡因含量[J].药学实践杂志,1998,16(6):355-357. |
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| 作者姓名： | 王海峰 王然 唐晓东 |
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| 作者单位： | 解放军第203医院!齐齐哈尔，161000，解放军第203医院!齐齐哈尔，161000，解放军第203医院!齐齐哈尔，161000 |
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| 摘 要： | 用反相HPLC法测定普鲁卡因和利多卡因的含量，并以外标法进行定量分析，采用238nm波长检测，Nova－ParC18柱，3．9×150mm，流动相甲醇－水－丁胺－冰醋酸（600：400：1．2：1V／F）。其中普鲁卡因的回收率99．76％，RSD0．530％。利多卡因回收率99．44％，RSD0．502％。其方法快速、准确、灵敏，样品处理简便易行。
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| 关 键 词： | HPLC 含量测定 普鲁卡因 利多卡因 |
A HPLC method for simultaneous determination of procaine and lidocaine in mixture |
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| Wang Haifeng,Wang Ran and Tang Xiaodong.A HPLC method for simultaneous determination of procaine and lidocaine in mixture[J].The Journal of Pharmaceutical Practice,1998,16(6):355-357. |
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| Authors: | Wang Haifeng Wang Ran and Tang Xiaodong |
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| Institution: | No. 203 Hospital of PLA, Qiqihaer, 161000;No. 203 Hospital of PLA, Qiqihaer, 161000;No. 203 Hospital of PLA, Qiqihaer, 161000 |
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| Abstract: | Procaine and Lidocaine in mixture were separated and simulboeously assayed by Reverse - phase HPLC, using Nova - pack C18 colum, 3.9 × 150min, a mixture of methyl alcohol, water, butylamine, acetic acide(600:400: 1. 2: 1 v/v) as mobile phase, external standard and 238um detector. The average recovery of 99.76% (RSD = 0.530% ), n = 3 for Lidocaine, 99. 44% (RSD 0.502% ) for procaine. The method is simple, rapid and acurate. The components have good liner relation and respative. |
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| Keywords: | Reveal-phase HPLC procaine Lidocaine |
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