| 马钱子的量效关系及毒性作用 |
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| 引用本文： | 孙成春,贾暖,王景祥. 马钱子的量效关系及毒性作用[J]. 药学实践杂志, 1998, 16(2): 84-86,107 |
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| 作者姓名： | 孙成春 贾暖 王景祥 |
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| 作者单位： | 济南军区总医院药理科!济南 250031 |
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| 摘 要： | 制马钱子在４０～８０ｍｇ／ｋｇ范围内，对小鼠具有明显的剂量依赖性抗炎镇痛作用，小于４０ｍｇ／ｋｇ时仅有抗炎作用，大于８０ｍｇ／ｋｇ时连续用药毒性增强，还可使小鼠胸腺重量明显增加。小鼠ｐｏ ＬＤ_５０为１４０．１３±１４．７４ｍｇ／ｋｇ。提示该药用量须适宜。
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| 关 键 词： | 马钱子 量效关系 毒性作用 中药 |
Dose-effect relationship and toxicity of Strychnos nux-vomica L |
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| Sun Chengchun,Jia Nuan and Wang Jingxiang. Dose-effect relationship and toxicity of Strychnos nux-vomica L[J]. The Journal of Pharmaceutical Practice, 1998, 16(2): 84-86,107 |
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| Authors: | Sun Chengchun Jia Nuan Wang Jingxiang |
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| Affiliation: | General Hospital of Jinan Military, Jinan 250031;General Hospital of Jinan Military, Jinan 250031;General Hospital of Jinan Military, Jinan 250031 |
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| Abstract: | It is evident that anti-inflammation and analgesia in dose-dependent of Strychnos nux-vomica L. from 40mg/kg to 80mg/kg, when the dose less than 40mg/kg it only showed anti-inflammation, its toxicity increased when more than 80mg/kg. Strychnos nux-vomica L. also might increase evidently the weight of thymus. The po LD50 in mice was 140.13±14.74mg/kg. The results suggested that the dose of Strychnos nux-vomica L. must be suitable. |
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| Keywords: | Strychnos nux - vomica L. dose - effect relationship toxicity |
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