| Wistar大鼠畸变产物耳声发射长期稳定性观察 |
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| 引用本文： | 田树昌,孙爱华,王剑超,范静平,林顺涨,杨毓梅,彭玉成. Wistar大鼠畸变产物耳声发射长期稳定性观察[J]. 听力学及言语疾病杂志, 2003, 11(1): 43-44,68 |
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| 作者姓名： | 田树昌 孙爱华 王剑超 范静平 林顺涨 杨毓梅 彭玉成 |
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| 作者单位： | 第二军医大学长征医院耳鼻咽喉科,上海,200003 |
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| 摘 要： | 目的：观察Wistar大鼠畸变产物耳声发射（DPOAE）长期稳定性。方法：对12只（21耳）健康、无耳疾病Wistar大鼠，分别于产后2、4、8、16周时测试F2为553、783、1105、1560、2211、3125、4416、6250、837Hz各点DPOAE（2f1-f2,f2/f1=1.2,L1=L2=70dB SPL)幅值。结果：除2周龄Wistar大鼠在F2为553、783、1105Hz三点DPOAE幅值较其后各周低，且差异有显著性意义（P＜0．05）外，其他各周龄在各频率点DPOAE幅值差异均无显著性意义（P＞0．05）。结论：4－16周龄Wistar大鼠DPOAE幅值在各频率点相对稳定，DPOAE可作为4－16周龄Wistar大鼠听力跟踪实验的指标，以此判断相应时期内耳蜗功能的改变。
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| 关 键 词： | Wistar大鼠 畸变产物耳声发射 耳蜗毛细胞 |
| 文章编号： | 1006-7299(2003)01-0043-03 |
Long - term Stability of Distortion Product Otoacoustic Emissions in Wistar Rats |
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| Tian Shuchang,Sun Aihua,Wang Jianchao,et al.. Long - term Stability of Distortion Product Otoacoustic Emissions in Wistar Rats[J]. Journal of Audiology and Speech Pathology, 2003, 11(1): 43-44,68 |
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| Authors: | Tian Shuchang Sun Aihua Wang Jianchao et al. |
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| Abstract: | Objective To observe the long-term changes in distortion product otoacoustic emissions (DPOAE) in Wistar rats.Methods 12(21ears) healthy Wistar rats were selected 2 weeks after birth.The DPOAE audiogram (F 2=553,783,1 105,1 560,2 211,3 125,4 416,6 250,8 837 Hz,2f 1-f 2,f 2/f 1=1.2,L 1=L 2=70 dB SPL)were measured and analyzed at 2,4,8,16 weeks after birth .Results Fewer changes were observed in level of DPOAE amplitudes at each frequency 4 weeks after birth ( P >0.05). Conclusion The results suggest that the DPOAE levels in Wistar rats have a good long-term stability at each frequency since 4 weeks after birth. It may be used as models for the evaluation of long-term changes of cochlear function. |
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| Keywords: | Distortion product otoacoustic emissions Wistar Rats Cochlear hair cells |
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