Increased number of peripheral blood CD34+ cells in lithium-treated patients |
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Authors: | Ami Ballin Dan Lehman Pinkhas Sirota Ulia Litvinjuk & Dina Meytes |
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Institution: | Paediatric Haematology Unit, Department of Haematology, Laboratory of Clinical Immunology, The E. Wolfson Medical Centre, Holon, The Abarbanel Mental Health Centre, Bat-Yam, and The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel |
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Abstract: | Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells. Following lithium therapy for 3–4 weeks their neutrophil counts increased by a mean of 88% (from 4625 ± 1350 × 109/l, mean ± SD pretreatment, to a peak of 8300 ± 3910 × 109/l). Concommitantly, there was a significant increment in their CD34+ cells (from 0.11 ± 0.01% to a peak of 0.18 ± 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34+ cells ( r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34+ cells for marrow transplantation. |
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Keywords: | lithium neutrophilia CD34+ cells bone marrow transplantation |
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