透析方式不影响慢性肾衰患者血浆内皮素、心钠素和甲状旁腺素水平的变化

对１２例持续非卧床腹膜透析（ＣＡＰＤ）维持一年以上和１６例维持一年以上血液透析的慢性肾衰透析患者（其中９例合并高血压），用放射免疫分析测定血浆内皮素（ＥＴ）、心钠素（ＡＮＰ）和甲状旁腺素（ＰＴＨ）的水平，以观察经ＨＤ和ＣＡＰＤ的慢性肾衰患者血浆ＥＴ、ＡＮＰ和ＰＴＨ的变化。慢性肾衰患者血浆ＥＴ、ＡＮＰ和ＰＴＨ浓度均较对照组显著升高，而透析８周前、后差异不显著，合并高血压的透析患者ＥＴ、ＡＮＰ和ＰＴＨ较对照组显著升高，但与无高血压的透析组比，差异也不显著。结果表明ＥＴ、ＡＮＰ和ＰＴＨ在慢性肾衰的发病机制中起重要作用，但ＣＡＰＤ与ＨＤ对ＥＴ、ＡＮＰ和ＰＴＨ水平的影响无明显差异。

Plasma Levels of Endothelin ,Atrial Natriuretic Peptide and Parathyroid Hormone Not Affected by Dialysis in Uremic Patients

Plasma levels of endothelin (ET),atrial natriuretic peptide (ANP) and parathyroid hormone (PTH) were measured by RIA in 12 patients with chronic renal failure maintained by continuous ambulatory peritoneal dialysis (CAPD) for more than one year and 16 patients by hemodialysis (HD) over one year (9 of them complicated by hypertension) to study the effect of CAPD and HD. Plasma levels of ET, ANP and PTH were increased in patients with chronic renal failure than in the controls,but no difference was found between their concentrations at the start and end of 8 weeks of dialysis. Higher plasma levels of ET,ANP and PTH were also observed in patients complicated by hypertension,however ,they were not significantly different from those of patients without hypertension. It is suggested that ET,ANP and PTH play an important role in the development of chronic renal failure,but their levels do not change after a period of CAPD and HD.